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Pain School®
Pain School®
at the University of Siena at the University of Siena at the University of Siena


EPS 2019 • Headaches and Facial Pain

Headaches and Facial Pain

Siena, Italy • 9-16 June 2019

Siena, Italy • 9-16 June 2019



Ln Faculty Lectures (L1-L20)
Wn Interactive Workshops, Seminars and Special Presentations (W1-W9)
Sn Scholars’ Oral Presentations (S1-S26)

  • Sunday, 9 June

    11:00-18:00 Arrival of Scholars and Faculty at the Certosa di Pontignano

    Assignment to rooms in the hotel wing of the Certosa. All food during the week will be provided by the restaurant of the Certosa (breakfast, lunch and dinner).

    15:30-16:30 A short guided tour through the Certosa, its Chapel, Cloisters and Garden
    17:00-18:30 Opening Ceremony
    18:30 Wine reception followed by dinner, then leisure time


  • Monday, 10 June

    9:00-10:00 L1 The voltage-gated sodium channels (NaV) of pain
    Peter Reeh (Erlangen, Germany)
    10:00-10:15 S1 Suppression of neuropathic pain by selective silencing of DRG ectopia using non-blocking concentrations of lidocaine
    Shai-lee Yatziv (Jerusalem, Israel)
    10:15-10:30 S2 Silent cold-sensing neurons drive cold allodynia in neuropathic pain
    Donald Iain MacDonald (London, United Kingdom)
    10:30-11:00 Coffee break
    11:00-11:15 S3 Photosensitization of TRPA1 and TRPV1 by 7-dehydrocholesterol: implications for the Smith-Lemli-Opitz syndrome
    Cosmin Ciotu (Bucharest, Romania)
    11:15-11:30 S4 Dural calcitonin gene-related peptide produces female-specific responses in rodent migraine models
    Amanda Avona (Dallas, TX, USA)
    11:30-12:30 L2 Insights into migraine pathophysiology from genetic animal models of the disease
    Daniela Pietrobon (Padua, Italy)
    13:00-15:00 Lunch break
    15:00-16:00 L3 A 30-years journey of CGRP: from the alternative splicing to migraine treatment
    Pierangelo Geppetti (Florence, Italy)
    16:00-16:15 S5 Investigation of gene expression changes in animal models of trigeminal sensitization
    Timea Aczél (Pécs, Hungary)
    16:15-16:30 S6 Fractalkine-induced hyperexcitability of spinal dorsal horn neurons in an animal model of non-specific back pain
    Vivian Blechschmidt (Mannheim, Germany)
    16:30-17:00 Coffee break
    17:00-17:15 S7 Glycinergic neurotransmission in pain sensitization
    Karolina Werynska (Zürich, Switzerland)
    17:15-17:30 S8 Stress, orofacial pain and headache disorders
    Oakley Morgan (London, United Kingdom)
    17:30-18:30 L4 The descending modulatory system of pain
    Lenaic Monconduit (Clermont-Ferrand, France)
    20:00-21:30 Dinner in the small Cloister
    21:30 W1
    Ugo Basile Srl. Gemonio, Varese, Italy


  • Tuesday, 11 June

    9:00-10:00 L5 eHealth and mHealth in the treatment of pain: a new era to reach out for patients!?
    Janosch A. Priebe (Munich, Germany)
    10:00-10:15 S9 Oleanolic acid promotes orofacial antinociception in adult zebrafish (Danio rerio) through TRPV1 receptors
    Adriana Barros (Fortaleza, Brazil)
    10:15-10:30 S10 Serotonin receptor subtypes expressed in primary cultures from rat dorsal root ganglia
    Dan Domocos (Bucharest, Romania)
    10:30-11:00 Coffee break
    11:00-11:15 S11 Botulinum toxin type A reduces inflammatory hypernociception induced by arthritis in the temporomadibular joint of rats
    Victor Muñoz Lora (Piracicaba, São Paulo, Brazil)
    11:15-11:30 S12 The effect of insulin on the nociceptive efferent function in meningeal tissues
    Judit Rosta (Szeged, Hungary))
    11:30-12:30 L6 The role of TRPA1 in inflammatory, neuropathic and migraine pain
    Pierangelo Geppetti (Florence, Italy)
    13:00-15:00 Lunch break
    15:00-16:00 L7 The trigemino-vascular system involvement in migraine
    Lenaic Monconduit (Clermont-Ferrand, France)
    16:00-16:15 S13 Role of endogenous descending inhibition in effects of intramuscular heating-needle stimulation in Freund’s Adjuvant-induced muscle nociception in rats
    Jing Lei (Helsinki, Finland)
    16:15-16:30 S14 Generalization of learned pain modulation depends on explicit learning
    Daniel Kusko (Boulder, CO, USA)
    16:30-17:00 Coffee break
    17:00-17:15 S15 Diurnal fluctuations of pain thresholds in Wistar rats exposed to experimental mechanical, thermal and chemical noxious stimulation during the Harmattan in northern Nigeria
    Ahmed Sherif Isa (Zaria, Nigeria)
    17:15-17:30 S16 Molecular and functional study of the transient receptor potential melastatin 8 (TRPM8) cold receptor channel tyrosine phosphorylation
    Alexandra Manolache (Bucharest, Romania)
    17:30-18:30 L8 The relationship between somatisation and headache
    Antonella Ciaramella (Pisa, Italy)
    20:00-21:30 Dinner in the small Cloister
    21:30 W2 Experimental pain labs (Gepetti, Holland, Monconduit, Reeh) including MEDOC`s “Q-Sense small fiber test”


  • Wednesday, 12 June

    9:00-10:00 L9 Circadian regulation of Migraine-related pain
    Philip Holland (London, UK)
    10:00-10:15 S17 Presenteeism: The hidden costs of pain
    Greig Adams (Reading, United Kingdom)
    10:15-10:30 S18 How does the brain synchronize the perception of nociceptive and visual stimuli? A preliminary challenge to multisensory interaction
    Louise Manfron (Louvain, Belgium)
    10:30-11:00 Coffee break
    11:00-11:15 S19 The use of biofeedback in the treatment of headaches
    Anna Marków (Cracow, Poland)
    11:15-11:30 S20 Pain interference type and level guide the assessment process in chronic pain
    Teemu Miettinen (Helsinki, Finland)
    11:30-12:30 L10 Migraine therapies
    Cristina Tassorelli (Pavia, Italy)
    13:00-15:00 Lunch break
    15:00-16:00 L11 Role of melatonin in pain modulation
    Giancarlo Carli (Siena, Italy)
    16:00-16:15 S21 Complex role of hypnotizability in the cognitive control of pain
    Sybille Consoli (Pisa, Italy)
    16:15-16:30 S22 The effectiveness of physiotherapy compared to aerobic exercise for the reduction of the headache frequency in patients with migraine – a pragmatic and preference-based clinical trial
    Annika Schwarz (Hamburg, Germany)
    16:30-17:00 Coffee break
    17:00-17:15 S23 Genome-wide association analysis identifies potential risk loci for chronic postsurgical pain
    Roel van Reij (Maastricht, The Netherlands)
    17:15-17:30 S24 Replication study identifies polymorphisms behind migraine with and without depression - the role of the PRDM16, REST and ADGRL2 genes
    Peter Petschner (Budapest, Hungary)
    17:30-18:30 L12 Pain projection and referred pain - examples, hypotheses and questions
    Karl Messlinger (Erlangen, Germany)
    20:00-21:30 Dinner in the small Cloister
    W3 Organization of scholars’ Debate teams
    Moderator: Marshall Devor
    W4 Stargazing night... with Prof. Vincenzo Millucci


  • Thursday, 13 June

    9:00-10:00 L13 Migraine pathophysiology
    Cristina Tassorelli (Pavia, Italy)
    10:00-10:30 W5 Duetto on "CNS and PNS determinants of migraine"
    Moderator: Marshall Devor
    Faculty: Karl Messlinger and Philip Holland
    10:30-11:00 Coffee break
    11:00-11:30 W6 Duetto on "Which are the most promising targets to fight chronic inflammatory pain?"
    Moderator: Marshall Devor
    Faculty: Marzia Malcangio and Michael Boettger
    11:30-12:30 L14 Pathophysiology of injured nerve and the ignition hypothesis of trigeminal neuralgia
    Marshall Devor (Jerusalem, Israel)
    13:00-15:00 Lunch break
    Afternoon and Evening: excursion to Siena old town
    15:00-19:00 Free time for Scholars in Siena
    19:00-20:00 Aperitif in Piazza del Campo
    20:00-24:00 Free time for Scholars in Siena / Faculty Dinner
    (plan to return to the Certosa on your own)


  • Friday, 14 June

    9:00-10:00 L15 Neuroimmune interactions in chronic pain
    Marzia Malcangio (London, UK)
    10:00-10:15 S25 Efficacy of Acupuncture and Heat-Sensitive Moxibustion versus Electroacupuncture for Trigeminal Neuralgia
    Zhen Tan (Nanchang, China)
    10:15-10:30 S26 Warm acupuncture treatment of cervicogenic headache
    Li Xu (Nanchang, China)
    10:30-11:00 Coffee break
    11:00-12:00 L16 Inter- and intracellular signaling mechanisms determine the sensitivity of trigeminal ganglion neurons and their central projections
    Karl Messlinger (Erlangen, Germany)
    13:00-15:00 Lunch break
    15:00-16:00 L17 Clinical development for new pain therapies - requirements and challenges
    Michael Boettger (Wuppertal, Germany)
    16:00-16:30 W7 Pain Quiz
    Moderator: Peter Reeh
    16:30-17:00 Coffee break
    17:00-18:00 L18 Pain, nociception and loss-of-consciousness
    Marshall Devor (Jerusalem, Israel)
    20:00-21:30 Dinner in the small Cloister


  • Saturday, 15 June

    9:00-10:00 L19 Hormonal modulation of pain
    Anna Maria Aloisi (Siena, Italy)
    10:00-10:30 W8 Scholars’ Debates (group 1)
    Resolved: Neuropathic pain is a form of epilepsy in peripheral nerves
    Moderator: Marshall Devor
    10:30-11:00 Coffee break
    11:00-11:30 W8 Scholars’ Debates (group 2)
    Resolved: Headaches probably also occur in fish
    Moderator: Marshall Devor
    11:30-12:30 L20 Steps toward an ethical treatment of babies' pain
    Carlo V. Bellieni (Siena, Italy)
    12:30 W9 General discussion of the EPS experience and suggestions on how to modify/improve EPS in the future
    - Parting words from Anna Maria Aloisi
    13:00-15:00 Lunch break
    18:00-24:00 Farewell Party and music


  • Sunday, 16 June

      Departure from the Certosa di Pontignano